FIGURE

Figure 5

ID

ZDB-FIG-220131-699

Publication

Mei et al., 2022 - Disruption of PIKFYVE causes congenital cataract in human and zebrafish

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Figure 5

Characterization of vacuoles in pikfyve^?8 mutants.

(A) Time-lapse imaging indicating the dynamic changes of vacuole formation in the lens of 4-dpf pikfyve^?8 mutants. White arrows indicate the fusion process of two small vacuoles. (B) Representative images showing the lens of 3.5-dpf siblings and pikfyve^?8 mutants injected with gfp-rab5c mRNA. (C) Representative images showing lens of 3.5-dpf siblings and pikfyve^?8 mutants injected with gfp-rab7 mRNA. (D) Representative images showing lens of 3.5-dpf siblings and pikfyve^?8 mutants injected with gfp-rab11a mRNA. (E) Representative images showing lens of 3.5-dpf siblings and pikfyve^?8 mutants injected with mcherry-lc3b mRNA. All experiments were repeated three times. All the scale bars represent 10 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Figure 5

Figure 5

Characterization of vacuoles in pikfyve?8 mutants.

Characterization of vacuoles in pikfyve^?8 mutants.