FIGURE
Figure 2
- ID
- ZDB-FIG-220430-98
- Publication
- Yan et al., 2022 - Functional Study of TMEM163 Gene Variants Associated with Hypomyelination Leukodystrophy
- Other Figures
- All Figure Page
- Back to All Figure Page
Figure 2
Figure 2. Intracellular zinc flux assay of HeLa cells stably expressing wild-type and variant TMEM163 proteins. The HLD-linked variant TMEM163-L76P showed significantly enhanced zinc efflux, while the TMEM163-L76R variant displayed marked loss of zinc efflux activity that mimicked the inactive TMEM163-D124A-D128A mutant. Unmodified HeLa cells and stable cells expressing the TMEM163-E286K mutant were included as additional controls. Significance testing was performed using ANOVA with repeated measures followed by a post-hoc analysis using Tukey’s multiple comparisons test (p < 0.0001, n = 4 independent trials). Data are represented as means ± SEM. A.U., arbitrary unit.
|
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Cells