FIGURE

Figure 2

ID

ZDB-FIG-220520-3

Publication

Duclaux-Loras et al., 2022 - UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking

Other Figures

All Figure Page

Back to All Figure Page

Figure 2

Histopathological and ultrastructural MVID features in the intestinal epithelium of patient.

(A) PAS and CD10 staining in control, P1, P2, and P4 duodenal biopsies. Scale bars: 20 μm. (B–D) TEM of P1’s duodenal enterocytes showing ultrastructural features of MVID: regions containing vesicles and tubulovesicular structures (black arrowheads), enlarged lysosomes (green arrowheads), and swollen (i.e., stressed) endoplasmic reticulum (white arrowheads) as well as more or less complex or partially degraded MVIs (yellow arrowheads) and basolateral microvilli (pink arrowheads). Brush border showed defective microvilli anchored deep into the cytoplasm and thickened terminal web (blue arrowheads) or partially depleted microvilli (red arrowheads). Scale bars: 2 μm (B); 1 μm (C); 0.5 μm (D).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.