Figure 5 - figure supplement 2
- ID
- ZDB-FIG-230123-24
- Publication
- Sabharwal et al., 2022 - Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality
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lrpprc homozygous mutants do not display neuronal necrosis. (A) Representative images of 6 dpf wild-type and lrpprcGBT0235/GBT0235 mutants. Background neuronal necrosis was observed in the wild type as well as lrpprc homozygous siblings (magnification- 5×). (B) Individual spots were quantified in the neuronal region of interest across a series of images (blinded images) obtained from both genotypes and the number of such particle counts was not significant (p-value = 0.1797). Each individual data point represents a single embryo. p-Values were determined using the Mann-Whitney U test. (C) Hatching gland displaying programmed apoptosis during organogenesis at 2 dpf zebrafish embryo (Positive control for the AO assay; Figure 5—source data 1). |