FIGURE

Fig. 2

ID

ZDB-FIG-241126-40

Publication

Schmitner et al., 2024 - Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes

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Fig. 2

Gck shows nutrient dependent expression in the liver and constitutive expression in the endocrine islet at different developmental stages.

Whole mount in situ hybridization at 4 dpf shows gck expression in the developing liver as shown in lateral and ventral view (a and a’) and in the endocrine islet (a”). Expression at 5 dpf expands with the development of the liver (b and b’) and is constitutive in the islet (b”). At 6 dpf expression in the liver is almost undetectable (c and c’), while expression in the islet is visible (c”). Expression is prominent in fed 10 dpf larvae in the liver (d and d’). Expression in the islet in fed 10 dpf larvae is not detectable (d”), which is likely due to limited penetration of the RNA-probe. Scale bar: 100 µm and 20 µm.

Expression Data

Gene:	gck
Fish:	WT
Condition:	food availability
Anatomical Terms:	islet liver
Stage Range:	Day 4 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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