FIGURE

FIGURE 3

ID

ZDB-FIG-241213-44

Publication

Chan et al., 2024 - Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica

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FIGURE 3

Antioxidant treatment ameliorated osteoporosis in Gorab^Prx1 mutants. (a) NAC treatment plan. 4 weeks old Gorab^Prx1 mutants started drinking 1 mg/mL of the antioxidant N‐acetylcyteine (NAC) or vehicle for 8 weeks. (b) 3D rendering, (c) representative microCT images and quantitation of (d) percentage of trabecular bone volume (BV/TV); (e) trabecular number (Tb.N); (f) trabecular separation (Tb.Sp); and (g) trabecular thickness (Tb.N) at the proximal tibia of 12 weeks old female control and Gorab^Prx1 mice treated with NAC (N = 8–10). Scale bar = 500 μm. Scanned and analyzed with Scanco μCT40 at 10 μm. Histomorphometric analysis at the proximal tibia secondary spongiosa in control and NAC treated Gorab^Prx1 mutants for (h) number of osteoblast per bone perimeter (N.Ob/B.Pm) and (i) number of osteoclast per bone perimeter (N.Oc/B.Pm). (N = 5) *p < 0.05, **p < 0.01, ***p < 0.001, ns, no statistically significant difference (unpaired Welch's t‐test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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