Fig. 4

Timing and penetrance of ethanol sensitivity in bmp4 mutant larvae shows that palate defects occur when exposure is from 10 to 18 hpf. (A) Comparison of palate defects in bmp4 mutant larvae when ethanol exposure is initiated at 10 hpf, 14 hpf, 18 hpf, 22 hpf or 24 hpf. Ethanol exposure results in approximately 10 % of palate defects in bmp4 mutant larvae when ethanol exposure is initiated at 10 or 14 hpf. Ethanol exposures initiated at 18 hpf or after does not result in palate defects. "n” for each treatment group listed in Table 5. (B) Comparison of palate defects in bmp4 mutant larvae with increasing ethanol exposure doses initiated at 24 hpf. Increasing ethanol concentrations, from 1 % to 1.3 %, initiated at 24 hpf do not result in palate defects. “n” for each treatment group listed in Table 6.