FIGURE

Fig. 2

ID

ZDB-FIG-250313-59

Publication

Kalyn et al., 2024 - Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish

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Fig. 2

Impact on DAnergic neurons following the loss of nr4a2a and nr4a2b. (a–l) Schematic representation of OB and Hyp brain regions and the immunostaining of eGFP (green) and DAPI (blue) using sagittal cryosections. (m–q) Quantification of eGFP+ neurons in the OB, Tel, PPv, PTN, and Hyp using coronal cryosections (n = 4). One-way ANOVA. DF: Within group = 6–9, between groups = 2. m: F = 1.505, p = 0.2730; n: F = 0.6856, p = 0.5283; o: F = 1.179, p = 0.3699; p: F = 9.879, p = 0.0069; q: F = 1.1920, p = 0.3475. (r–s) dat and th1 gene expression levels in nr4a2a and nr4a2b mutants relative to WT (n = 3 brains). One-way ANOVA. DF: Within group =7, between groups =2. r: F = 2.8870, p = 0.1218; s: F = 33.56, p = 0.0003. Bars represent the Mean ± the SEM. *p < 0.05, ***p < 0.001. (Scale bar = 100 μm). OB, olfactory bulbs; Hyp, hypothalamus; PPv, periventricular pretectal nucleus; PTN, posterior tubercular nucleus; Tel, telencephalon.

Expression Data

Gene:	th
Fish:	nr4a2a^ot511/ot511; ot80Tg
Anatomical Term:	whole organism
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nr4a2a^ot511/ot511; ot80Tg
Observed In:	caudal tuberculum dopaminergic neuron hypothalamus dopaminergic neuron whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurochem.