FIGURE

Fig 5

ID

ZDB-FIG-260606-18

Publication

Biswas et al., 2026 - Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum

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Fig 5

Mutations in pcdh19 or pcdh17 lead to increased phenotypic variability.
A. Cumulative distribution of all pairwise within group r values for wild type (purple), pcdh19^-10bp (blue) pcdh19^Δprom (teal), and pcdh17^-5bp (orange) mutants. (**p < 0.001, Dunn’s test). B. Hypothesized roles of Pcdh19 and Pcdh17 in canalyzing the assembly of visual circuits in the zebrafish optic tectum. In the wild type scenario (left/purple), development is canalized and the outcomes (circuit response to visual stimulation) is restricted, showing a small distribution in outcomes (shaded Gaussian). In the case of protocadherin mutants (right/teal), the developmental landscape is flattened, allowing development to stochastically explore a variety of alternative paths, leading to an increased variation among outcomes (broad shaded distribution).

Expression Data

Gene:	GCaMP
Fish:	pcdh17^os69/os69; os78Tg/os78Tg pcdh19^os51/os51; os78Tg/os78Tg pcdh19^os77/os77; os78Tg/os78Tg
Condition:	lighting conditions
Anatomical Term:	optic tectum
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pcdh17^os69/os69; os78Tg/os78Tg pcdh19^os51/os51; os78Tg/os78Tg pcdh19^os77/os77; os78Tg/os78Tg
Condition:	lighting conditions
Observed In:	optic tectum optic tectum visual perception
Stage:	Day 6

Phenotype Detail

Acknowledgments

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