ZFIN is now using GRCz12tu for Genomic Data
Gene
robo1
- ID
- ZDB-GENE-000209-3
- Name
- roundabout, axon guidance receptor, homolog 1 (Drosophila)
- Symbol
- robo1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable axon guidance receptor activity. Predicted to be involved in several processes, including Roundabout signaling pathway; chemotaxis; and nervous system development. Predicted to be located in membrane. Is expressed in basal plate midbrain region; epidermis; nervous system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus 8; combined or isolated pituitary hormone deficiency 8; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d100 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive congenital nystagmus 8 | Alliance | ?Nystagmus 8, congenital, autosomal recessive | 257400 |
| combined or isolated pituitary hormone deficiency 8 | Alliance | Pituitary hormone deficiency, combined or isolated, 8 | 620303 |
| Neurooculorenal syndrome | 620305 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR032986 | Roundabout homologue 1, immunoglobulin-like domain 3 |
| Family | IPR051170 | Neural and epithelial cell adhesion domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers