ZFIN is now using GRCz12tu for Genomic Data
Gene
unc45b
- ID
- ZDB-GENE-020919-3
- Name
- unc-45 myosin chaperone B
- Symbol
- unc45b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Hsp90 protein binding activity. Involved in lens development in camera-type eye. Acts upstream of or within cardiac muscle tissue development; myofibril assembly; and skeletal muscle tissue development. Located in Z disc. Is expressed in several structures, including cardiovascular system; eye; mesoderm; musculature system; and myoblast. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb393 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 27 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 43 | Alliance | ?Cataract 43 | 616279 |
| myofibrillar myopathy 11 | Alliance | Myofibrillar myopathy 11 | 619178 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024660 | UNC-45/Cro1/She4, central domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR000225 | Armadillo |
| Repeat | IPR019734 | Tetratricopeptide repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | UNC-45/Cro1/She4, central domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DGE9 | InterPro | 934 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
unc45b-202
(1)
|
Ensembl | 521 nt | ||
| mRNA |
unc45b-201
(1)
|
Ensembl | 3,821 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-unc45b | polyclonal | Rabbit |
|
1 | |||
| Ab2-unc45b | polyclonal | Guinea pig |
|
2 |
Plasmids
- Genome Browsers