iqgap2

ID

ZDB-GENE-030131-2878

Name

IQ motif containing GTPase activating protein 2

Symbol

iqgap2 Nomenclature History

Previous Names

fc20f09
si:ch211-157p10.1
wu:fc20f09

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Acts upstream of or within glomerular filtration; heart development; and podocyte development. Predicted to be located in plasma membrane bounded cell projection. Predicted to be active in cell cortex. Is expressed in several structures, including cardiovascular system; gut; pronephros; sensory system; and yolk syncytial layer. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqgap2 Human Ortholog

No data available

Associated With iqgap2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000593	RasGAP protein, C-terminal
Domain	IPR001202	WW domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036872	CH domain superfamily