mtor

ID

ZDB-GENE-030131-2974

Name

mechanistic target of rapamycin kinase

Symbol

mtor Nomenclature History

Previous Names

ztor (1)
frap1
wu:fc22h08

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including defense response to bacterium; positive regulation of myelination; and regulation of TOR signaling. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; male organism; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

31 figures from 24 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144752 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtor Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Focal cortical dysplasia, type II, somatic	607341
		Smith-Kingsmore syndrome	616638

Associated With mtor Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR009076	FKBP12-rapamycin binding domain
Domain	IPR014009	PIK-related kinase
Domain	IPR024585	Serine/threonine-protein kinase mTOR domain
Domain	IPR026683	Serine/threonine-protein kinase TOR, catalytic domain
Family	IPR050517	DNA Damage Response and Repair Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036738	FKBP12-rapamycin binding domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily