ZFIN is now using GRCz12tu for Genomic Data
Gene
hmox1a
- ID
- ZDB-GENE-030131-3102
- Name
- heme oxygenase 1a
- Symbol
- hmox1a Nomenclature History
- Previous Names
-
- hmox1
- fc27c04
- wu:fc27c04
- zgc:65984 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables heme oxygenase (decyclizing) activity. Acts upstream of or within several processes, including regulation of granuloma formation; regulation of macrophage migration; and regulation of respiratory gaseous exchange. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including eye; heart; hematopoietic system; liver and biliary system; and neuroepithelial cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909276 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic obstructive pulmonary disease | Alliance | {Pulmonary disease, chronic obstructive, susceptibility to} | 606963 |
| Heme oxygenase-1 deficiency | 614034 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Haem oxygenase | Haem oxygenase conserved site | Haem oxygenase-like | Haem oxygenase-like, multi-helical |
|---|---|---|---|---|---|---|
| UniProtKB:B0UXS0 | InterPro | 272 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmox1a-201
(1)
|
Ensembl | 1,413 nt | ||
| mRNA |
hmox1a-202
(1)
|
Ensembl | 1,737 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hmox1a | polyclonal | Rabbit |
|
2 |
Plasmids
No data available
- Genome Browsers