ZFIN is now using GRCz12tu for Genomic Data
Gene
bptf
- ID
- ZDB-GENE-030131-3200
- Name
- bromodomain PHD finger transcription factor
- Symbol
- bptf Nomenclature History
- Previous Names
-
- fc30e02
- fc32a05
- wu:fb71f11
- wu:fc30e02
- wu:fc32a05
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone octamer slider activity. Acts upstream of or within cranial skeletal system development; neural plate anterior/posterior regionalization; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NURF complex. Is expressed in head and hematopoietic multipotent progenitor cell. Human ortholog(s) of this gene implicated in Kaposi's sarcoma; alcohol dependence; and neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Orthologous to human BPTF (bromodomain PHD finger transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with dysmorphic facies and distal limb anomalies | Alliance | Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies | 617755 |
| {Kaposi sarcoma, susceptibility to} | 148000 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR001510 | Zinc finger, PARP-type |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR018501 | DDT domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR028941 | WHIM2 domain |
| Family | IPR038028 | Nucleosome-remodeling factor subunit BPTF |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance