ZFIN is now using GRCz12tu for Genomic Data

Gene

tpp1

ID

ZDB-GENE-030131-6654

Name

tripeptidyl peptidase I

Symbol

tpp1 Nomenclature History

Previous Names

cln2
fa01b09
im:7149243
wu:fa01b09

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable endopeptidase activity and tripeptidyl-peptidase activity. Acts upstream of or within central nervous system development; locomotory behavior; and neurogenesis. Predicted to be located in lysosome. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and retinal neural layer. Used to study neuronal ceroid lipofuscinosis 2. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Orthologous to human TPP1 (tripeptidyl peptidase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149243 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 7	Alliance	Spinocerebellar ataxia, autosomal recessive 7	609270
neuronal ceroid lipofuscinosis 2	Alliance	Ceroid lipofuscinosis, neuronal, 2	204500

Associated With tpp1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
neuronal ceroid lipofuscinosis 2	tpp1^sa11/sa11	standard conditions	Mahmood et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000209	Peptidase S8/S53 domain
Domain	IPR015366	Peptidase S53, activation domain
Domain	IPR030400	Sedolisin domain
Family	IPR050819	Tripeptidyl-peptidase I and related peptidases
Homologous_superfamily	IPR036852	Peptidase S8/S53 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Peptidase S53, activation domain	Peptidase S8/S53 domain	Peptidase S8/S53 domain superfamily	Sedolisin domain	Tripeptidyl-peptidase I and related peptidases
UniProtKB:A0A8M2B594	InterPro	556
UniProtKB:F8W2M8	InterPro	557

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpp1-201 (1) Ensembl	Ensembl	868 nt	Select Tool ZFIN BLAST
mRNA	tpp1-203 (1) Ensembl	Ensembl	2,054 nt	Select Tool ZFIN BLAST
ncRNA	tpp1-002 (1) Ensembl	Ensembl	735 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tpp1		tpp1		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations