ZFIN is now using GRCz12tu for Genomic Data
Gene
gnb1a
- ID
- ZDB-GENE-030131-823
- Name
- guanine nucleotide binding protein (G protein), beta polypeptide 1a
- Symbol
- gnb1a Nomenclature History
- Previous Names
-
- gnb1 (1)
- wu:fb50b09
- wu:fj94h04
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable signaling receptor complex adaptor activity. Acts upstream of or within positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including blastomere; brain; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, acute lymphoblastic, somatic | 613065 |
| autosomal dominant intellectual developmental disorder 42 | Alliance | Intellectual developmental disorder, autosomal dominant 42 | 616973 |
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001632 | G-protein, beta subunit |
| Family | IPR016346 | Guanine nucleotide-binding protein, beta subunit |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein, beta subunit | G-protein beta WD-40 repeat | Guanine nucleotide-binding protein, beta subunit | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PH57 | InterPro | 340 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers