ZFIN is now using GRCz12tu for Genomic Data
Gene
sparc
- ID
- ZDB-GENE-030131-9
- Name
- secreted protein, acidic, cysteine-rich (osteonectin)
- Symbol
- sparc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to be located in basement membrane and extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910025 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 17 | Alliance | Osteogenesis imperfecta, type XVII | 616507 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Conserved_site | IPR001999 | Osteonectin-like, conserved site |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR015369 | Follistatin/Osteonectin EGF domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Domain | IPR037641 | SPARC, follistatin-like domain |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Osteonectin-like, conserved site | SPARC, follistatin-like domain | SPARC/Testican, calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQH0 | InterPro | 291 | |||||||||
| UniProtKB:A0AB32T306 | InterPro | 282 | |||||||||
| UniProtKB:A0AC58H5M1 | InterPro | 165 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sparc-201
(1)
|
Ensembl | 1,724 nt | ||
| mRNA |
sparc-202
(1)
|
Ensembl | 865 nt | ||
| mRNA |
sparc-203
(1)
|
Ensembl | 544 nt | ||
| mRNA |
sparc-206
(1)
|
Ensembl | 520 nt | ||
| mRNA |
sparc-207
(1)
|
Ensembl | 2,567 nt | ||
| ncRNA |
sparc-005
(1)
|
Ensembl | 836 nt | ||
| ncRNA |
sparc-006
(1)
|
Ensembl | 726 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers