ZFIN is now using GRCz12tu for Genomic Data
Gene

mmp2

ID
ZDB-GENE-030131-9123
Name
matrix metallopeptidase 2
Symbol
mmp2 Nomenclature History
Previous Names
  • Gelatinase A (1)
  • wu:fa99h12
  • wu:fk89d01
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hematopoietic stem cell migration; lymph vessel development; and neurogenesis. Located in sarcomere. Is expressed in several structures, including cardiovascular system; digestive system; integument; nervous system; and ovarian follicle. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
59 figures from 40 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Multicentric osteolysis, nodulosis, and arthropathy 259600
Associated With mmp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Domain IPR000562 Fibronectin type II domain
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Additional Resources Length Fibronectin type II domain Fibronectin type II domain superfamily Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Kringle-like fold Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10, metallopeptidase Peptidase, metallopeptidase PGBD-like superfamily
UniProtKB:Q7SZM5 InterPro 657
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mmp2-201 (1)
Ensembl
Ensembl 3,033 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mmp2 polyclonal IgG Rabbit
  • IHC
  • WB
 AnaSpec
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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