Gene

ddx18

ID

ZDB-GENE-030131-9685

Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

Symbol

ddx18 Nomenclature History

Previous Names

cb155 (1)
fa19d11
sb:cb155
wu:fa19d11 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and RNA binding activity. Acts upstream of or within myeloid cell differentiation. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and trunk vasculature. Orthologous to human DDX18 (DEAD-box helicase 18).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb155 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx18 Human Ortholog

No data available

Associated With ddx18 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR025313	ATP-dependent rRNA helicase SPB4-like, C-terminal extension
Domain	IPR044773	DDX18/Has1, DEAD-box helicase domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase