ZFIN is now using GRCz12tu for Genomic Data
Gene
tp63
- ID
- ZDB-GENE-030819-1
- Name
- tumor protein p63
- Symbol
- tp63 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA binding activity. Involved in regulation of ectodermal cell fate specification. Acts upstream of or within several processes, including epidermis morphogenesis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of programmed necrotic cell death. Located in nucleus. Is expressed in several structures, including brain; digestive system; ectoderm; gonad; and integument. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu912 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ADULT syndrome | Alliance | ADULT syndrome | 103285 |
| ankyloblepharon-ectodermal defects-cleft lip/palate syndrome | Alliance | Hay-Wells syndrome | 106260 |
| ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 | Alliance | Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 | 604292 |
| orofacial cleft 8 | Alliance | Orofacial cleft 8 | 618149 |
| Rapp-Hodgkin syndrome | Alliance | Rapp-Hodgkin syndrome | 129400 |
| split hand-foot malformation 4 | Alliance | Split-hand/foot malformation 4 | 605289 |
| Limb-mammary syndrome | 603543 | ||
| Premature ovarian failure 21 | 620311 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR010991 | p53, tetramerisation domain |
| Domain | IPR011615 | p53, DNA-binding domain |
| Domain | IPR037611 | Tumour protein p63, SAM domain |
| Family | IPR002117 | p53 tumour suppressor family |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036674 | p53-like tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tumour protein p63, SAM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JFE3 | InterPro | 576 | |||||||||
| UniProtKB:Q8JHZ5 | InterPro | 457 | |||||||||
| UniProtKB:Q8JHZ6 | InterPro | 588 | |||||||||
| UniProtKB:A0AB32TPJ2 | InterPro | 580 | |||||||||
| UniProtKB:A0AB32TPJ7 | InterPro | 375 | |||||||||
| UniProtKB:A0A8M1PDU3 | InterPro | 588 | |||||||||
| UniProtKB:A0AB32TT28 | InterPro | 681 | |||||||||
| UniProtKB:A0AB32TUR6 | InterPro | 673 | |||||||||
| UniProtKB:A0AB32TVK7 | InterPro | 619 | |||||||||
| UniProtKB:A0AB32TWG3 | InterPro | 592 | |||||||||
| UniProtKB:A0AB32TWL1 | InterPro | 669 | |||||||||
| UniProtKB:A0AB32TWM7 | InterPro | 685 | |||||||||
| UniProtKB:A0AB32TXS5 | InterPro | 648 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tp63-201
(1)
|
Ensembl | 2,783 nt | ||
| mRNA |
tp63-202
(1)
|
Ensembl | 2,959 nt | ||
| mRNA |
tp63-203
(1)
|
Ensembl | 1,444 nt | ||
| mRNA |
tp63-204
(1)
|
Ensembl | 2,497 nt | ||
| mRNA |
tp63-205
(1)
|
Ensembl | 1,731 nt | ||
| mRNA |
tp63-206
(1)
|
Ensembl | 3,084 nt | ||
| mRNA |
tp63-207
(1)
|
Ensembl | 2,955 nt | ||
| mRNA |
tp63-208
(1)
|
Ensembl | 1,305 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tp63 | monoclonal | IgG2a , k | Mouse |
|
Biocare
Santa Cruz Biotechnology, Inc. Millipore Novus Biologicals, LLC Abcam plc |
62 |
Plasmids
No data available
- Genome Browsers