ZFIN is now using GRCz12tu for Genomic Data
Gene
mmp14a
- ID
- ZDB-GENE-030901-1
- Name
- matrix metallopeptidase 14a (membrane-inserted)
- Symbol
- mmp14a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; retinal ganglion cell axon guidance; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including axis; head; head mesenchyme; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb386 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Winchester syndrome | Alliance | Winchester syndrome | 277950 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Conserved_site | IPR018486 | Hemopexin, conserved site |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR002477 | Peptidoglycan binding-like |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR021805 | Peptidase M10A, matrix metallopeptidase, C-terminal |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Additional Resources | Length | Hemopexin, conserved site | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10A, matrix metallopeptidase, C-terminal | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | Peptidoglycan binding-like | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2J2 | InterPro | 574 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mmp14a-201
(1)
|
Ensembl | 3,509 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers