ZFIN is now using GRCz12tu for Genomic Data
Gene
tjp1a
- ID
- ZDB-GENE-031001-2
- Name
- tight junction protein 1a
- Symbol
- tjp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within pigmentation and slit diaphragm assembly. Located in bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 53 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb817 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000906 | ZU5 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR035597 | ZO-1, SH3 domain |
| Family | IPR005417 | Tight junction protein ZO |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tjp1a-201
(1)
|
Ensembl | 4,902 nt | ||
| mRNA |
tjp1a-202
(1)
|
Ensembl | 6,999 nt | ||
| mRNA |
tjp1a-203
(1)
|
Ensembl | 676 nt | ||
| mRNA |
tjp1a-204
(1)
|
Ensembl | 612 nt | ||
| mRNA |
tjp1a-205
(1)
|
Ensembl | 485 nt | ||
| mRNA |
tjp1a-206
(1)
|
Ensembl | 1,035 nt | ||
| mRNA |
tjp1a-207
(1)
|
Ensembl | 544 nt | ||
| mRNA |
tjp1a-209
(1)
|
Ensembl | 206 nt | ||
| mRNA |
tjp1a-210
(1)
|
Ensembl | 784 nt | ||
| mRNA |
tjp1a-211
(1)
|
Ensembl | 5,101 nt | ||
| mRNA |
tjp1a-212
(1)
|
Ensembl | 5,074 nt | ||
| ncRNA |
tjp1a-004
(1)
|
Ensembl | 751 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tjp1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision) |
248 | |
| Ab2-tjp1 | polyclonal | Rabbit |
|
Life Technologies (Invitrogen)
|
24 | ||
| Ab5-tjp1a | polyclonal | Rabbit |
|
2 | |||
| Ab4-tjp1a | polyclonal | Rabbit |
|
1 |
Plasmids
No data available
- Genome Browsers