erbb2

ID

ZDB-GENE-031118-121

Name

erb-b2 receptor tyrosine kinase 2

Symbol

erbb2 Nomenclature History

Previous Names

wu:fv70f10
zgc:63601

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including glial cell development; heart development; and mesenchymal cell differentiation. Predicted to be located in several cellular components, including early endosome; perinuclear region of cytoplasm; and ruffle membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erbb2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lung cancer	Alliance	Adenocarcinoma of lung, somatic	211980
ovarian cancer	Alliance	Ovarian cancer, somatic	167000
stomach cancer	Alliance	Gastric cancer, somatic	613659
		Glioblastoma, somatic	137800
		?Visceral neuropathy, familial, 2, autosomal recessive	619465

Associated With erbb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR032778	Growth factor receptor domain 4
Domain	IPR049328	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat