ZFIN is now using GRCz12tu for Genomic Data
Gene
hif1al
- ID
- ZDB-GENE-040426-1315
- Name
- hypoxia inducible factor 1 subunit alpha, like
- Symbol
- hif1al Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including erythrocyte development; response to activity; and response to hypoxia. Part of beta-catenin-TCF complex. Is active in nucleus. Is expressed in several structures, including digestive system; head; muscle; nervous system; and pleuroperitoneal region. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63965 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR021537 | Hypoxia-inducible factor, alpha subunit-like |
| Family | IPR001067 | Nuclear translocator |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Hypoxia-inducible factor, alpha subunit-like | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2E4 | InterPro | 571 | ||||||||
| UniProtKB:A0A8M9QBW4 | InterPro | 564 | ||||||||
| UniProtKB:A0A0R4IB28 | InterPro | 619 | ||||||||
| UniProtKB:A0A0R4IBR4 | InterPro | 626 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hif1al-201
(1)
|
Ensembl | 900 nt | ||
| mRNA |
hif1al-202
(1)
|
Ensembl | 5,161 nt | ||
| mRNA |
hif1al-203
(1)
|
Ensembl | 3,185 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hif1al | polyclonal | Rabbit |
|
4 |
Plasmids
- Genome Browsers