ZFIN is now using GRCz12tu for Genomic Data
Gene
pyroxd1
- ID
- ZDB-GENE-040426-1732
- Name
- pyridine nucleotide-disulphide oxidoreductase domain 1
- Symbol
- pyroxd1 Nomenclature History
- Previous Names
-
- ryroxd1 (1)
- zgc:73254
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable flavin adenine dinucleotide binding activity; oxidoreductase activity, acting on NAD(P)H; and oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor. Predicted to be located in cytosol; nucleus; and sarcomere. Is expressed in female organism and trunk musculature. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73254 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from O'Grady et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myofibrillar myopathy 8 | Alliance | Myopathy, myofibrillar, 8 | 617258 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR041575 | NADH-rubredoxin oxidoreductase, C-terminal |
| Family | IPR050260 | FAD-dependent oxidoreductase |
| Homologous_superfamily | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-dependent oxidoreductase | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | NADH-rubredoxin oxidoreductase, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PBT5 | InterPro | 490 | |||||
| UniProtKB:A0A0R4IEM7 | InterPro | 485 | |||||
| UniProtKB:A0AC58J5Z8 | InterPro | 485 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pyroxd1-201
(1)
|
Ensembl | 4,462 nt | ||
| mRNA |
pyroxd1-202
(1)
|
Ensembl | 2,226 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ryroxd1 |
|
Abmart
|
2 |
Plasmids
No data available
- Genome Browsers