ZFIN is now using GRCz12tu for Genomic Data
Gene

uhrf1

ID
ZDB-GENE-040426-2039
Name
ubiquitin-like with PHD and ring finger domains 1
Symbol
uhrf1 Nomenclature History
Previous Names
  • fb97f09
  • NP95 (1)
  • unm b1115
  • unm_b1115
  • wu:fb97f09
  • zgc:63539
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable several functions, including hemi-methylated DNA-binding activity; methylated histone binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including intestinal epithelial structure maintenance; lens development in camera-type eye; and negative regulation of gene expression via chromosomal CpG island methylation. Is active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and presumptive neural retina. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
41 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With uhrf1 Human Ortholog
No data available
Associated With uhrf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
Domain IPR000626 Ubiquitin-like domain
Domain IPR001841 Zinc finger, RING-type
Domain IPR001965 Zinc finger, PHD-type
Domain IPR003105 SRA-YDG
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR021991 UHRF1, tandem tudor domain
Domain IPR047406 E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain
Family IPR045134 UHRF1/2-like
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR015947 PUA-like superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036987 SRA-YDG superfamily
Domain Details Per Protein
Protein Additional Resources Length E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain PUA-like superfamily SRA-YDG SRA-YDG superfamily Ubiquitin-like domain Ubiquitin-like domain superfamily UHRF1/2-like UHRF1, tandem tudor domain Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, PHD-type, conserved site Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site
UniProtKB:E7EZF3 InterPro PDB 776
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA uhrf1-201 (1)
Ensembl
Ensembl 5,079 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-uhrf1 polyclonal Rabbit
  • IHC
 1
Ab1-uhrf1 polyclonal Rabbit
  • WB
 2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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