ZFIN is now using GRCz12tu for Genomic Data
Gene
rad51
- ID
- ZDB-GENE-040426-2286
- Name
- RAD51 recombinase
- Symbol
- rad51 Nomenclature History
- Previous Names
-
- wu:fb38e12
- zgc:77754
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Predicted to be involved in DNA recombination and chromosome organization involved in meiotic cell cycle. Predicted to be active in condensed nuclear chromosome. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; mirror movements 2; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77754 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| Fanconi anemia complementation group R | Alliance | Fanconi anemia, complementation group R | 617244 |
| mirror movements 2 | Alliance | Mirror movements 2 | 614508 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | rad51sa23805/sa23805 | standard conditions | Botthof et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | Rad51-like, C-terminal |
| Domain | IPR020587 | DNA recombination and repair protein RecA, monomer-monomer interface |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR011941 | DNA recombination/repair protein Rad51 |
| Family | IPR016467 | DNA recombination and repair protein, RecA-like |
| Homologous_superfamily | IPR010995 | DNA repair Rad51/transcription factor NusA, alpha-helical |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA recombination and repair protein RecA, monomer-monomer interface | DNA recombination/repair protein Rad51 | DNA repair Rad51/transcription factor NusA, alpha-helical | P-loop containing nucleoside triphosphate hydrolase | Rad51-like, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TYR1 | InterPro | 340 | ||||||||
| UniProtKB:A0AC58I2J2 | InterPro | 347 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers