rpl11

ID

ZDB-GENE-040625-147

Name

ribosomal protein L11

Symbol

rpl11 Nomenclature History

Previous Names

zgc:86748

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within several processes, including erythrocyte development; glucose homeostasis; and hemoglobin biosynthetic process. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in endodermal cell; eye; intestine; liver; and pancreas. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 37 figures from 16 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rpl11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Diamond-Blackfan anemia 7	Alliance	Diamond-Blackfan anemia 7	612562

Associated With rpl11 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Diamond-Blackfan anemia	WT + MO1-rpl11	standard conditions	(3)
Diamond-Blackfan anemia	rpl11^{hi3820bTg/hi3820bTg}	standard conditions	(2)
Diamond-Blackfan anemia	rpl11^{hi3820bTg/hi3820bTg}	standard conditions	(3)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020929	Large ribosomal subunit protein uL5, conserved site
Domain	IPR031309	Large ribosomal subunit protein uL5, C-terminal
Domain	IPR031310	Large ribosomal subunit protein uL5, N-terminal
Family	IPR002132	Large ribosomal subunit protein uL5
Homologous_superfamily	IPR022803	Large ribosomal subunit protein uL5 domain superfamily