socs1a

ID

ZDB-GENE-040801-205

Name

suppressor of cytokine signaling 1a

Symbol

socs1a Nomenclature History

Previous Names

socs1 (1)
zgc:91868

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine receptor binding activity. Acts upstream of or within several processes, including positive regulation of T cell migration; regulation of signal transduction; and regulation of tyrosine phosphorylation of STAT protein. Is expressed in several structures, including brain; digestive system; musculature system; pleuroperitoneal region; and visual system. Used to study hyperinsulinism and steatotic liver disease. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91868 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With socs1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoinflammatory syndrome, familial, with or without immunodeficiency	619375

Associated With socs1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
steatotic liver disease	socs1a^ihb33/ihb33 (AB)	standard conditions	Dai et al., 2015
steatotic liver disease	socs1a^ihb29/ihb29 (AB)	standard conditions	Dai et al., 2015
hyperinsulinism	socs1a^ihb33/+ (AB)	standard conditions	Dai et al., 2015