Gene

crbn

ID

ZDB-GENE-040822-43

Name

cereblon

Symbol

crbn Nomenclature History

Previous Names

zgc:92404 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Involved in fin development; limb development; and otic vesicle development. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92404 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crbn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 2	Alliance	Intellectual developmental disorder, autosomal recessive 2	607417

Associated With crbn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003111	Lon protease, N-terminal domain
Domain	IPR004910	Yippee/Mis18/Cereblon
Domain	IPR034750	CULT domain
Homologous_superfamily	IPR015947	PUA-like superfamily
Homologous_superfamily	IPR046336	Lon protease, N-terminal domain superfamily