ZFIN is now using GRCz12tu for Genomic Data
Gene
pomcb
- ID
- ZDB-GENE-041014-294
- Name
- proopiomelanocortin b
- Symbol
- pomcb Nomenclature History
- Previous Names
-
- pomc-like (1)
- si:ch211-203k16.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hormone activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; gonad; and head. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shi et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Opiodes neuropeptide | Pro-opiomelanocortin | Pro-opiomelanocortin/corticotropin, ACTH, central region | Pro-opiomelanocortin-derived peptides |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NCD8 | InterPro | 215 | ||||
| UniProtKB:A0AC58I1Q1 | InterPro | 215 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-pomc | monoclonal | IgG1 | Mouse |
|
LifeSpan BioSciences, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers