ZFIN is now using GRCz12tu for Genomic Data
Gene
nrg1
- ID
- ZDB-GENE-050302-113
- Name
- neuregulin 1
- Symbol
- nrg1 Nomenclature History
- Previous Names
-
- wu:fm70e01
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable chemorepellent activity and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including enteric nervous system development; fin regeneration; and neurogenesis. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in embryonic structure; gut; heart; nervous system; and somite. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 34 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| schizophrenia 6 | Alliance | {?Schizophrenia, susceptibility to} | 603013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002154 | Neuregulin, C-terminal |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR040180 | Neuregulin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neuregulin | Neuregulin, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QKS2 | InterPro | 417 | |||||||||
| UniProtKB:A0A8M3B1W6 | InterPro | 724 | |||||||||
| UniProtKB:A0A0R4IBM0 | InterPro | 730 | |||||||||
| UniProtKB:A0A1B4Z255 | InterPro | 604 | |||||||||
| UniProtKB:A0A0R4IDP7 | InterPro | 725 | |||||||||
| UniProtKB:A0A8M3B1T9 | InterPro | 729 | |||||||||
| UniProtKB:B3DK99 | InterPro | 599 | |||||||||
| UniProtKB:A0A8M6Z0Q7 | InterPro | 412 | |||||||||
| UniProtKB:A0A0R4IFE6 | InterPro | 687 | |||||||||
| UniProtKB:A0A8M9QGQ0 | InterPro | 404 | |||||||||
| UniProtKB:A0A8M3B955 | InterPro | 692 | |||||||||
| UniProtKB:A0A0R4IPH3 | InterPro | 722 | |||||||||
| UniProtKB:A0AB32TZ68 | InterPro | 721 |
Interactions and Pathways
No data available
Plasmids