ZFIN is now using GRCz12tu for Genomic Data
Gene
cdk10
- ID
- ZDB-GENE-050417-94
- Name
- cyclin dependent kinase 10
- Symbol
- cdk10 Nomenclature History
- Previous Names
-
- zgc:110252 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables histone kinase activity. Acts upstream of or within negative regulation of neuron apoptotic process; neurogenesis; and post-translational protein modification. Predicted to be active in nucleus. Is expressed in brain; eye; liver; and pleuroperitoneal region. Orthologous to human CDK10 (cyclin dependent kinase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110252 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Yeh et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Al Kaissi syndrome | 617694 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044093 | Cyclin-dependent kinase 10, catalytic domain |
| Family | IPR050108 | Cyclin-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Cyclin-dependent kinase 10, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWS0 | InterPro | 288 | ||||||
| UniProtKB:F1QKU6 | InterPro | 360 | ||||||
| UniProtKB:A0A8M3AZU9 | InterPro | 340 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cdk10 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers