abcd1

ID

ZDB-GENE-050517-27

Name

ATP-binding cassette, sub-family D (ALD), member 1

Symbol

abcd1 Nomenclature History

Previous Names

zgc:172102 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable several functions, including ATP binding activity; fatty acyl-CoA hydrolase activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including oligodendrocyte development; positive regulation of myelination; and swimming behavior. Acts upstream of or within cholesterol transport. Predicted to be located in peroxisome. Predicted to be active in peroxisomal membrane. Is expressed in central nervous system; floor plate; gut; interrenal gland; and pronephros. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Strachan et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcd1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adrenoleukodystrophy	Alliance	Adrenoleukodystrophy	300100
adrenoleukodystrophy	Alliance	Adrenomyeloneuropathy, adult	300100

Associated With abcd1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
adrenoleukodystrophy	abcd1^zc92/zc92	standard conditions	Raas et al., 2021
adrenoleukodystrophy	abcd1^sa509/sa509	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR050835	ATP-binding cassette sub-family D
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily