ZFIN is now using GRCz12tu for Genomic Data
Gene
nr3c1
- ID
- ZDB-GENE-050522-503
- Name
- nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Symbol
- nr3c1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables nuclear glucocorticoid receptor activity. Acts upstream of or within several processes, including chondrocyte proliferation; monoatomic cation transport; and response to glucocorticoid. Located in cytoplasm and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; gill; and pleuroperitoneal region. Used to study depressive disorder and generalized anxiety disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; cocaine abuse; heroin dependence; and lung disease (multiple). Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113038 (1 image)
- dq017615 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 59 figures from 22 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glucocorticoid resistance | 615962 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| depressive disorder | nr3c1s357/s357 | standard conditions | Ziv et al., 2013 |
| generalized anxiety disorder | nr3c1s357/s357 | standard conditions | Sireeni et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001409 | Glucocorticoid receptor |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucocorticoid receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1XHK0 | InterPro | 746 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers