tnfb

ID

ZDB-GENE-050601-2

Name

tumor necrosis factor b (TNF superfamily, member 2)

Symbol

tnfb Nomenclature History

Previous Names

TNF2 (1)
tnf
lta (1)
TNF-alpha 2 (1)
Tnf-alpha (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within defense response to bacterium; immune response; and liver development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; heart; male organism; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 33 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Qi et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnfb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, susceptibility to}	600807
immunodeficiency 127	Alliance	?Immunodeficiency 127	620977
migraine	Alliance	{Migraine without aura, susceptibility to}	157300
		{Dementia, vascular, susceptibility to}
		{Malaria, cerebral, susceptibility to}	611162
		{Septic shock, susceptibility to}

Associated With tnfb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006052	Tumour necrosis factor domain
Family	IPR002960	Lymphotoxin-alpha
Family	IPR006053	Tumour necrosis factor
Homologous_superfamily	IPR008983	Tumour necrosis factor-like domain superfamily