Gene
grk1a
- ID
- ZDB-GENE-050823-1
- Name
- G protein-coupled receptor kinase 1 a
- Symbol
- grk1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables rhodopsin kinase activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; retina; retinal photoreceptor layer; and retinal rod cell. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oguchi disease-2 | Alliance | Oguchi disease-2 | 613411 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR016137 | RGS domain |
| Domain | IPR037716 | Rhodopsin kinase, catalytic domain |
| Family | IPR000239 | GPCR kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Rhodopsin kinase, catalytic domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1XHM0 | InterPro | 563 |
Interactions and Pathways
No data available
Plasmids
No data available