mpi

ID

ZDB-GENE-050904-6

Name

mannose phosphate isomerase

Symbol

mpi Nomenclature History

Previous Names

im:7140016
zgc:110773

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables mannose-6-phosphate isomerase activity. Acts upstream of or within chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to be active in cytosol. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7140016 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mpi Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of glycosylation Ib	Alliance	Congenital disorder of glycosylation, type Ib	602579

Associated With mpi Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital disorder of glycosylation type I	AB + MO1-mpi	standard conditions	Chu et al., 2013
congenital disorder of glycosylation type I	WT + MO1-mpi	standard conditions	DeRossi et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018050	Phosphomannose isomerase, type I, conserved site
Domain	IPR046456	Phosphomannose isomerase type I, C-terminal domain
Domain	IPR046457	Phosphomannose isomerase type I, catalytic domain
Domain	IPR046458	Phosphomannose isomerase type I, helical insertion domain
Family	IPR001250	Mannose-6-phosphate isomerase, type I
Family	IPR016305	Mannose-6-phosphate isomerase
Homologous_superfamily	IPR011051	RmlC-like cupin domain superfamily
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold