tfpi2

ID

ZDB-GENE-060503-38

Name

tissue factor pathway inhibitor 2

Symbol

tfpi2 Nomenclature History

Previous Names

si:ch211-262k23.2 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including heart development; regulation of hemopoiesis; and sarcomere organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; eye; heart; liver; and ovary. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Zhang et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfpi2 Human Ortholog

No data available

Associated With tfpi2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
Domain	IPR002223	Pancreatic trypsin inhibitor Kunitz domain
Family	IPR008296	Tissue factor pathway inhibitor-like
Family	IPR050098	Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like
Homologous_superfamily	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily