Gene

acaca

ID

ZDB-GENE-060526-74

Name

acetyl-CoA carboxylase alpha

Symbol

acaca Nomenclature History

Previous Names

acc (1)
fj43d01
im:7138837 (1)
si:ch211-199d18.1
wu:fj43d01 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable acetyl-CoA carboxylase activity. Acts upstream of or within response to (R)-carnitine. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in female organism; liver; male organism; subcutaneous fat; and visceral fat. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

37 figures from 32 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acaca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Acetyl-CoA carboxylase deficiency	613933

Associated With acaca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001882	Biotin-binding site
Domain	IPR000089	Biotin/lipoyl attachment
Domain	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain	IPR005481	Biotin carboxylase-like, N-terminal domain
Domain	IPR005482	Biotin carboxylase, C-terminal
Domain	IPR011761	ATP-grasp fold
Domain	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain	IPR011764	Biotin carboxylation domain
Domain	IPR013537	Acetyl-CoA carboxylase, central domain
Domain	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Domain	IPR049074	Acetyl-CoA carboxylase, BT domain
Family	IPR049076	Acetyl-CoA carboxylase
Homologous_superfamily	IPR011053	Single hybrid motif
Homologous_superfamily	IPR011054	Rudiment single hybrid motif
Homologous_superfamily	IPR013815	ATP-grasp fold, subdomain 1
Homologous_superfamily	IPR016185	Pre-ATP-grasp domain superfamily
Homologous_superfamily	IPR029045	ClpP/crotonase-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M6YZ52	InterPro	2349
UniProtKB:A0A8M9PK80	InterPro	2425
UniProtKB:A0A8M9QE20	InterPro	2326
UniProtKB:A0A2R8QJA0	InterPro	2375
UniProtKB:A0A8M9Q3F9	InterPro	2348
UniProtKB:A0A8M6Z6X1	InterPro	2368
UniProtKB:A0A8M6Z6C9	InterPro	2341
UniProtKB:A0A8M9Q8Q1	InterPro	2391
UniProtKB:F6P055	InterPro	2383
UniProtKB:A0A8M9PK85	InterPro	2383
UniProtKB:A0A8M9Q3F2	InterPro	2418
UniProtKB:A0A8M1NZ82	InterPro	2390
UniProtKB:A0A8M9QE14	InterPro	2410
UniProtKB:A0A8M6YY91	InterPro	2356
UniProtKB:A0A8M9PXQ3	InterPro	2376

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	acaca-201 (1) Ensembl	Ensembl	8,344 nt	Select Tool ZFIN BLAST
mRNA	acaca-202 (1) Ensembl	Ensembl	8,498 nt	Select Tool ZFIN BLAST
ncRNA	acaca-002 (1) Ensembl	Ensembl	662 nt	Select Tool ZFIN BLAST
ncRNA	acaca-003 (1) Ensembl	Ensembl	514 nt	Select Tool ZFIN BLAST
ncRNA	acaca-004 (1) Ensembl	Ensembl	834 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab4-acaca	polyclonal	acaca		Rabbit	WB	Sangon Biotech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations