ZFIN is now using GRCz12tu for Genomic Data
Gene
fas
- ID
- ZDB-GENE-061019-2
- Name
- Fas cell surface death receptor
- Symbol
- fas Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable tumor necrosis factor receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; motor neuron apoptotic process; and necroptotic signaling pathway. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; digestive system; eye; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including cystic fibrosis; hematologic cancer (multiple); multiple sclerosis (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ferrari et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome | Alliance | Autoimmune lymphoproliferative syndrome, type IA | 601859 |
| autoimmune lymphoproliferative syndrome | Alliance | {Autoimmune lymphoproliferative syndrome} | 601859 |
| Squamous cell carcinoma, burn scar-related, somatic |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR033998 | Fas receptor, death domain |
| Domain | IPR034055 | Tumor necrosis factor receptor 6, N-terminal, teleost |
| Family | IPR008063 | Fas receptor |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | Fas receptor | Fas receptor, death domain | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 6, N-terminal, teleost |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QG24 | InterPro | 293 | ||||||
| UniProtKB:A0A8N7UR03 | InterPro | 294 | ||||||
| UniProtKB:A0ACD6B665 | InterPro | 294 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers