ZFIN is now using GRCz12tu for Genomic Data
Gene
aopep
- ID
- ZDB-GENE-070410-115
- Name
- aminopeptidase O (putative)
- Symbol
- aopep Nomenclature History
- Previous Names
-
- cb974 (1)
- wu:fa96d09
- wu:fc79b08
- zgc:162939
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to act upstream of or within proteolysis. Predicted to be active in nucleolus. Is expressed in central nervous system; lateral line system; neural tube; pectoral fin; and tail bud. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb974 (6 images)
- IMAGE:7162376 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dystonia 31 | Alliance | Dystonia 31 | 619565 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014782 | Peptidase M1, membrane alanine aminopeptidase |
| Domain | IPR015211 | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal |
| Family | IPR033577 | Aminopeptidase O |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR027268 | Peptidase M4/M1, CTD superfamily |
| Homologous_superfamily | IPR038502 | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily |
| Homologous_superfamily | IPR042097 | Aminopeptidase N-like , N-terminal domain superfamliy |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminopeptidase N-like , N-terminal domain superfamliy | Aminopeptidase O | Armadillo-type fold | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily | Peptidase M1, membrane alanine aminopeptidase | Peptidase M4/M1, CTD superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0V1A5 | InterPro | 787 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aopep-206
(1)
|
Ensembl | 2,364 nt | ||
| mRNA |
zgc:162939-201
(1)
|
Ensembl | 2,626 nt | ||
| mRNA |
zgc:162939-202
(1)
|
Ensembl | 799 nt | ||
| mRNA |
zgc:162939-204
(1)
|
Ensembl | 760 nt | ||
| mRNA |
zgc:162939-205
(1)
|
Ensembl | 987 nt | ||
| ncRNA |
zgc:162939-005
(1)
|
Ensembl | 824 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers