ZFIN is now using GRCz12tu for Genomic Data
Gene
faslg
- ID
- ZDB-GENE-070410-16
- Name
- Fas ligand (TNF superfamily, member 6)
- Symbol
- faslg Nomenclature History
- Previous Names
-
- FasL (1)
- zgc:162027
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Acts upstream of or within notochord development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; digestive system; eye; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ferrari et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome | Alliance | Autoimmune lymphoproliferative syndrome, type IB | 601859 |
| lung cancer | Alliance | {Lung cancer, susceptibility to} | 211980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q0PKX7 | InterPro | 268 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers