cdkn1a

ID

ZDB-GENE-070705-7

Name

cyclin dependent kinase inhibitor 1A

Symbol

cdkn1a Nomenclature History

Previous Names

cip1
p21
waf1
si:ch1073-48m5.2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein kinase inhibitor activity. Acts upstream of or within aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

125 figures from 112 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdkn1a Human Ortholog

No data available

Associated With cdkn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003175	Cyclin-dependent kinase inhibitor domain
Family	IPR029841	Cyclin-dependent kinase inhibitor 1
Homologous_superfamily	IPR044898	Cyclin-dependent kinase inhibitor domain superfamily