Gene
ppargc1a
- ID
- ZDB-GENE-080505-1
- Name
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
- Symbol
- ppargc1a Nomenclature History
- Previous Names
-
- PGC1 (1)
- ppargc1al
- gb:dq017637
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Acts upstream of or within aerobic electron transport chain and skeletal muscle tissue development. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017637 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | PGC-1 | PGC-1alpha, RNA recognition motif | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z0A6 | InterPro | 884 | |||||
| UniProtKB:A0A8M6Z7F8 | InterPro | 885 | |||||
| UniProtKB:A0A8M1REN0 | InterPro | 873 | |||||
| UniProtKB:A0A8M6Z1V5 | InterPro | 872 | |||||
| UniProtKB:A0AB32TTT1 | InterPro | 938 | |||||
| UniProtKB:A0AB32TU67 | InterPro | 1152 | |||||
| UniProtKB:A0AB32TVI9 | InterPro | 937 | |||||
| UniProtKB:A0AB32TZQ3 | InterPro | 925 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppargc1a-201
(1)
|
Ensembl | 2,580 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-ppargc1a | polyclonal | Rabbit |
|
Abcam plc
|
4 |
Plasmids
No data available