fbxw7

ID

ZDB-GENE-090313-79

Name

F-box and WD repeat domain containing 7

Symbol

fbxw7 Nomenclature History

Previous Names

si:ch211-208n2.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within angiogenesis; negative regulation of myelination; and regulation of signal transduction. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in glioblast (sensu Vertebrata); neural tube; neuroblast (sensu Vertebrata); spinal cord; and trunk. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fbxw7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental delay, hypotonia, and impaired language	Alliance	Developmental delay, hypotonia, and impaired language	620012

Associated With fbxw7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001810	F-box domain
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036047	F-box-like domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B7ZDC8	InterPro
UniProtKB:B8A474	InterPro
UniProtKB:F1RCB5	InterPro
UniProtKB:A0A8M9Q490	InterPro	834
UniProtKB:A0A8M9Q0J4	InterPro	761
UniProtKB:A0A8M9PRD0	InterPro	606
UniProtKB:A0A8M9Q8H7	InterPro	605
UniProtKB:A0A8M2BI81	InterPro	545
UniProtKB:A0A8M9PIU0	InterPro	835
UniProtKB:A0A8M3APF2	InterPro	830