cd40lg

ID

ZDB-GENE-100727-1

Name

CD40 ligand

Symbol

cd40lg Nomenclature History

Previous Names

cd154 (2)
TNFSF5 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables CD40 receptor binding activity. Acts upstream of or within positive regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cd40lg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
CD40 ligand deficiency	Alliance	Immunodeficiency, X-linked, with hyper-IgM	308230
X-linked hyper IgM syndrome	Alliance	Immunodeficiency, X-linked, with hyper-IgM	308230

Associated With cd40lg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR021184	Tumour necrosis factor, conserved site
Domain	IPR006052	Tumour necrosis factor domain
Homologous_superfamily	IPR008983	Tumour necrosis factor-like domain superfamily