lrp4

ID

ZDB-GENE-130129-1

Name

low density lipoprotein receptor-related protein 4

Symbol

lrp4 Nomenclature History

Previous Names

eni
nui

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone binding activity. Acts upstream of or within establishment of synaptic specificity at neuromuscular junction and neuromuscular synaptic transmission. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in apical plasma membrane. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cenani-Lenz syndactyly syndrome	Alliance	Cenani-Lenz syndactyly syndrome	212780
congenital myasthenic syndrome 17	Alliance	?Myasthenic syndrome, congenital, 17	616304
sclerosteosis 2	Alliance	Sclerosteosis 2	614305

Associated With lrp4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
bone development disease	AB + MO1-lrp4	control	Tian et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR000033	LDLR class B repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A2R8PYI8	InterPro	968
UniProtKB:A0A8M6Z1W5	InterPro	1913
UniProtKB:A0AC58G1R7	InterPro	1817
UniProtKB:A0AC58G1S0	InterPro	1044
UniProtKB:A0AC58G1S1	InterPro	1801
UniProtKB:A0AC58G1S2	InterPro	1913
UniProtKB:A0AC58G1S5	InterPro	1060
UniProtKB:A0AC58G1S6	InterPro	1897