lrp4

ID

ZDB-GENE-130129-1

Name

low density lipoprotein receptor-related protein 4

Symbol

lrp4 Nomenclature History

Previous Names

eni
nui

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone binding activity. Acts upstream of or within axon regeneration; establishment of synaptic specificity at neuromuscular junction; and neuromuscular synaptic transmission. Predicted to be part of receptor complex. Predicted to be active in apical plasma membrane. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cenani-Lenz syndactyly syndrome	Alliance	Cenani-Lenz syndactyly syndrome	212780
congenital myasthenic syndrome 17	Alliance	?Myasthenic syndrome, congenital, 17	616304
sclerosteosis 2	Alliance	Sclerosteosis 2	614305

Associated With lrp4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
bone development disease	AB + MO1-lrp4	control	Tian et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR000033	LDLR class B repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A2R8PYI8	InterPro	968
UniProtKB:A0A8M6Z1W5	InterPro	1913
UniProtKB:A0AC58G1R7	InterPro	1817
UniProtKB:A0AC58G1S0	InterPro	1044
UniProtKB:A0AC58G1S1	InterPro	1801
UniProtKB:A0AC58G1S2	InterPro	1913
UniProtKB:A0AC58G1S5	InterPro	1060
UniProtKB:A0AC58G1S6	InterPro	1897