ZFIN is now using GRCz12tu for Genomic Data
Gene
nppb
- ID
- ZDB-GENE-130530-642
- Name
- natriuretic peptide B
- Symbol
- nppb Nomenclature History
- Previous Names
-
- bnp (1)
- si:ch211-215j19.10
- zmp:0000000639
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hormone activity and hormone receptor binding activity. Acts upstream of or within atrioventricular canal development; cardiac jelly development; and cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in atrium; cardiac ventricle; heart; and heart tube. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Natriuretic peptide | Natriuretic peptide, brain type | Natriuretic peptide, conserved site | Natriuretic Peptide Hormone |
|---|---|---|---|---|---|---|
| UniProtKB:F1R8L8 | InterPro | 129 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance